2-bromo-3-nitro pyridine

Name	2-Bromo-3-nitropyridine
Synonyms	2-BroMo-3-nitropyrid 2-BROMO-3-NITROPYRIDINE 2-Bromo-3-nitropyridine 2-bromo-3-nitro pyridine Pyridine, 2-bromo-3-nitro- 2-Bromo-3-nitropyridine in stock Factory
CAS	19755-53-4
EINECS	625-152-0
InChI	InChI=1/C5H3BrN2O2/c6-5-4(8(9)10)2-1-3-7-5/h1-3H
InChIKey	ZCCUFLITCDHRMG-UHFFFAOYSA-N

Molecular Formula	C5H3BrN2O2
Molar Mass	202.99
Density	1.8727 (rough estimate)
Melting Point	122-125 °C (lit.)
Boling Point	244.0±20.0 °C(Predicted)
Flash Point	101.4°C
Vapor Presure	0.0485mmHg at 25°C
Appearance	White-like powder
BRN	124504
pKa	-3.24±0.10(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Refractive Index	1.6200 (estimate)
MDL	MFCD00955613

Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S22 - Do not breathe dust.
WGK Germany	3
HS Code	29333990
Hazard Class	IRRITANT

Properties	2-bromo-3-nitropyridine is gray-white to cream-colored crystalline powder at room temperature and pressure. It is a pyridine derivative and has the general properties of the pyridine ring.
Use	2-bromo-3-nitropyridine can be used as an intermediate in pharmaceutical chemistry and organic synthesis. In the synthesis and transformation, the nitro group on the pyridine ring can be reduced to amino group; affected by the electron-deficient properties of the pyridine ring and the strong electron-withdrawing properties of the nitro group, the bromine atom in the structure can be easily attacked by nucleophiles such as alkylamines or oxygen anions to obtain further derivatized products.
synthesis method	48% hydrobromic acid (2.31 ml, 20 mmol) solution dissolved in dimethyl sulfoxide (25 ml) is added dropwise to 2-amino -3-nitropyridine ((0.986g, 5 mmol) in a mixed system of 25 ml dimethyl sulfoxide and potassium nitrite (0.851g, 10 mmol), the resulting mixture was stirred at 35°C and then transferred to a solution containing potassium carbonate (5g) in 100 ml of ice water, then the reaction mixture was dissolved in ether, the ether extract was washed with water and dried with anhydrous magnesium sulfate. Remove the organic solvent under reduced pressure to obtain crude 4-bromobenzophenone. The crude product was further purified by column chromatography to obtain 2-bromo-3-nitropyridine. Figure 2-Bromo-3-nitropyridine synthesis route

Last Update：2024-04-09 21:04:16

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2-bromo-3-nitro pyridine

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